Alternative Non-Testing methods Assessed for REACH Substances

September 8th, 2011

Potential models for REACH endpoints available now!

We have compiled the list of available models potentially usable for REACH: CLICK HERE

REACH legislation states that Non-Testing Methods (NTM) can be used within REACH. These methods include Quantitative Structure-Activity Relationship (QSAR) models and read-across. Before making an animal experiment the industry should verify if alternative methods exist. However, so far there is a deep gap of knowledge on which methods are available and can be used in practice.

ANTARES aims to reduce this gap assessing NTM as an alternative approach for the REACH legislation.

  • to verify the possible use and performance of the non-testing methods for REACH;
  • to identify requirements and constraints originating from the REACH legislation which may affect the non-testing methods;
  • to identify safety assessment factors for the non-testing methods;
  • to identify the best applicability criteria for a safer use of the non-testing methods;
  • to integrate different non-testing methods, achieving superior performance;
  • to disseminate the results;
  • to promote non-testing methods for legislative purposes.

The main result will be a characterization of the non-testing methods suitable for REACH.

The project is organized in 13 Actions:
Action 1.
Survey of current methods for the compliance to the REACH legislation.
Action 2.
Identification of the criteria for the non-testing methods for the REACH legislation.
Action 3.
Identification of suitable experimental databases/data sets for the ecotoxicological, toxicological and environmental endpoints for REACH.
Action 4.
List of (Q)SAR models for the ecotoxicological, toxicological and environmental endpoints for REACH, and their review.
Action 5.
Validation of non-testing methods.
Action 6.
Identification of boundaries for best use of models (applicability domain) and of the assessment factors.
Action 7.
Architecture for integration of different non-testing methods for best performances and coverage of applicability.
Action 8.
Communication and Dissemination initiatives.
Action 9.
Web Portal.
Action 10.
Project Management.
Action 11.
Action 12.
Action 13.
After-LIFE Communication plan.

The LIFE Programme is the EU’s financial instrument supporting environmental and nature conservation projects throughout the EU, as well as in some candidate, acceding and neighbouring countries. Since 1992, LIFE has co-financed some 3115 projects, contributing approximately €2 billion to the protection of the environment.

The ANTARES project (Grant Agreement LIFE08 ENV/IT/00435) is funded under the LIFE+ Environment Policy and Governance component,which supports technological projects that offer significant environmental benefits, for example process or efficiency improvements.

This part of LIFE+ (the current phase of the programme, running from 2007-2013) also helps projects that improve the implementation of EU environmental legislation, that build the environmental policy knowledge base, and that develop environmental information sources through monitoring (including forest monitoring).


ANTARES official final report available

Friday, March 21st, 2014


The QSAR2014 workshop website is open

The 16th International Workshop on Quantitative Structure-Activity Relationships in Environmental and Health Sciences (QSAR2014) will take place on June 16-20, 2014

Monday, July 8th, 2013


New software for ADMET available

Wednesday, April 3rd, 2013


E-book "Theory, guidance and applications on QSAR and REACH" available for download.

Thursday, November 29th, 2012



FINAL WORKSHOP with ANTARES results - dedicated to industry and regulators.

Wednesday, November 21st - Thursday 22nd 2012



Italian Event for Industry: "8ª Conferenza Sicurezza Prodotti - A che punto siamo con il REACH"

Thursday, March 8th, 2012


Course: "Il metodo QSAR e le sue applicazioni pratiche nel Regolamento REACH"

Tuesday, March 6th, 2012


ANTARES Brochure now available

Wednesday, November 16nd, 2011


eLEARNING: new section for learning QSARs is now open

Monday, October 3rd, 2011



Italian Working group on QSAR and REACH launched by the Ministero della Salute

Friday, September 23rd, 2011


List of potential software for QSAR for REACH

Thursday, September 22nd, 2011


ANTARES presented at European Environmental Agency

Tuesday, September 13th, 2011


VEGA, a new public platform for QSAR and read across for REACH

Monday, September 12th, 2011


ANTARES Newsletter n. 2 available

Evaluation of NTM and Laboratory Survey - Presentation of the Results

Wednesday, July 13th, 2011


ANTARES presented at SETAC

2 posters, 1 oral presentation and a course

Thursday, May 19th, 2011